Bahador is working with Rachel Lopez to integrate these metabolite measures into models of cardiomyocyte crossbridge function and force generation which then can be inserted into models of the heart and cardiovascular system to predict pressure-volume loops in the left ventricle and aortic blood pressure.
- Cross bridge contraction model based on metabolite level and reliable Ca handling. (Cross bridge model)
- Whole body cardiovascular dynamic model (TriSeg model and lumped circulatory model)
- Energetics model for metabolite prediction (Ox-Phos model)
- How do changes in metabolite pools contribute to the mechanical failure of the heart?