Ca2+ Uniporter


Ca2+ is taken up in energized mitochondria via the Ca2+ uniporter (CU).  It is driven by the electrochemical gradient of Ca2+ across the inner mitochondrial membrane (IMM).  It is also influenced by the kinetics of Ca2+ binding to the CU.  CU plays a major role in mitochondrial function or dysfunction by regulating the dynamics of mitochondrial [Ca2+].

Dash, RK and Beard, DA.  Analysis of Cardiac Mitochondrial Na+/Ca2+ Exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+ Handing Suggests a 3:1 Stoichiometry. J Physiol, 2008.