Effect of Regulatory Architecture on Broad versus Narrow Sense Heritability

Additive genetic variance (VA) and total genetic variance (VG) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reportedVA/VG ratios from line-cross experiments is not well understood. Here we report how the VA/VGratio, and thus the ratio between narrow and broad sense heritability (h2/H2), varies as a function of the regulatory architecture underlying genotype-to-phenotype (GP) maps.

Parameters in dynamic models of complex traits are containers of missing heritability

Polymorphisms identified in genome-wide association studies of human traits rarely explain more than a small proportion of the heritable variation, and improving this situation within the current paradigm appears daunting. Given a well-validated dynamic model of a complex physiological trait, a substantial part of the underlying genetic variation must manifest as variation in model parameters. These parameters are themselves phenotypic traits.

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