CT Perfusion; Cardiac CT; Dynamic CT; Kinetic Modeling; Myocardial Blood Flow

Simulation Evaluation of Quantitative Myocardial Perfusion Assessment from Cardiac CT

Contrast enhancement on cardiac CT provides valuable information about myocardial perfusion and methods have been proposed to assess perfusion with static and dynamic acquisitions. There is a lack of knowledge and consensus on the appropriate approach to ensure 1) sufficient diagnostic accuracy for clinical decisions and 2) low radiation doses for patient safety. This work developed a thorough dynamic CT simulation and several accepted blood flow estimation techniques to evaluate the performance of perfusion assessment across a range of acquisition and estimation scenarios.

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