Effect of Regulatory Architecture on Broad versus Narrow Sense Heritability
Additive genetic variance (VA) and total genetic variance (VG) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reportedVA/VG ratios from line-cross experiments is not well understood. Here we report how the VA/VGratio, and thus the ratio between narrow and broad sense heritability (h2/H2), varies as a function of the regulatory architecture underlying genotype-to-phenotype (GP) maps.
