Abstract
Cerebral autoregulation (CA) is a local process modulating vessel properties to maintain cerebral blood flow (CBF) despite fluctuations in arterial blood pressure (ABP). Four mechanisms contribute to regulate flow. The myogenic response describes the influence of circumferential mechanical stresses and strains on vascular smooth muscle cell tone. During the neurogenic response, astrocytes sense neural activity and regulate CBF via end feet. The metabolic response corrects the mismatch between neurogenic flow increase and CBF demand. The shear-dependent response is characterized by the produc#on of nitric oxide by the endothelium. Previous models aim to describe either sta#c CA (steady-state ABP/CBF relationship) or dynamic CA (transient CBF response). This work proposes a simple patient-specific model predicting transient CBF velocity (CBFV) that describes both static and dynamic CA responses.